Huberfeld G, Kubis N, Lot G, Ripoll L, Chaine P, Drouet L & Woimant F. G20210a prothrombin gene mutation in two siblings with cerebral venous thrombosis. Neurology 1998; 51(1): 316-7.

Baulac S, Huberfeld G, An-Gourfinkel I, Brice A, LeGuern E, Escayg A, MacDonald BT, Meisler MH, Moulard B, Chaigne D, Buresi C & Malafosse A. Mutations of scn1a, encoding a neuronal sodium channel, in two families with gefs+2. Nat Genet 2000; 24(4): 343-5.

Sharshar T, Chevret S, Mazighi M, Chillet P, Huberfeld G, Berreotta C, Houfani M & Gajdos P. Validity and reliability of two muscle strength scores commonly used as endpoints in assessing treatment of myasthenia gravis. J Neurol 2000; 247(4): 286-90.

Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme JF, Baulac M, Brice A, Bruzzone R & LeGuern E. First genetic evidence of gaba(a) receptor dysfunction in epilepsy: A mutation in the gamma2-subunit gene. Nat Genet 2001; 28(1): 46-8.

Huberfeld G, Dupont S, Hazemann P, Adam C, Baulac M & Pierrot-Deseilligny C. Recurrent idiopathic stupor in a patient: Responsability of exogenous or endogenous benzodiazepines?. Rev Neurol (Paris) 2002; 158(8-9): 824-6.


Cohen I, Navarro V, Huberfeld G, Clemenceau S, Baulac M & Miles R. Response to comment on "on the origin of interictal activity in human temporal lobe epilepsy in vitro". Science 2003; 301(5632): 463.

Baulac S, Gourfinkel-An I, Nabbout R, Huberfeld G, Serratosa J, Leguern E & Baulac M. Fever, genes, and epilepsy. Lancet Neurology 2004; 3(7):421-30.


Huberfeld G, Habert MO, Clemenceau S, Maksud P, Baulac M & Adam C. Contralateral propagation of epileptic seizures studied with SPECT: the Mirror Image. Epilepsia 2006; 47(1):123-133.

Menendez de la Prida L, Huberfeld G, Cohen I & Miles R. Threshold Behavior in the Initiation of Hippocampal Population Bursts. Neuron 2006; 49(1):131–42.

Cohen I, Huberfeld G & Miles R. Emergence of disinhibition induced synchrony in the CA3 region of the hippocampus in vitro. J Physiol 2006;570(Pt 3):583-94.

Huberfeld G, Wittner L, Kaila K, Clemenceau S, Miles R & Rivera C. Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci 2007; 27(37):9866–9873.

Pallud J, Devaux B, Miles R, Huberfeld G. Hippocampal Seizures. J Neurosurg 2009;110:399.

Wittner L, Huberfeld G, Clemenceau S, Erőss L, Dezamis E, Entz L, Ulbert I, Baulac M & Miles R. The epileptic human hippocampal CA2 region generates spontaneous interictal like activity in vitro. Brain 2009;132(11):3022-46.


Huberfeld G, Menendez de la Prida L, Pallud J, Cohen I, LevanQuyen M, Clemenceau S, Baulac M & Miles R. Glutamatergic pre-ictal discharges emerge at the transition to seizure in the human epilepsy. Nature Neurosciences 2011;14(5):627-34.


Sabolek H, Swiercz W, Lillis K, Cash S, Huberfeld G, Zhao G, Ste-Marie L, Clemenceau S, Barsh G, Miles R, Staley K. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci 2012; 32(9):3009-21


Degos B, Daelman L, Huberfeld G, Meppiel E, Rabier D, Galanaud D, Magis G, Lyon-Caen O, Samuel D, Sedel F. Portosystemic shunts: An underdiagnosed but treatable cause of neurological and psychiatric disorders. Journal of the Neurological Sciences 2012;321(1-2):58-64.

Huberfeld G, Le Duigou C, Le Van Quyen M, Navarro V, Baulac M & Miles R. The paradox of the paroxysm: can human seizure precipitants help understand ictogenesis? The Neuroscientist 2013 Oct;19(5):523-40


Pallud J, Capelle L, Huberfeld G. Tumoral epileptogenicity: How does it happen? Epilepsia.     2013;54(Suppl 9):30-4


Pallud J, Audureau E, Blonski M, Sanai N, Bauchet L, Fontaine D, Mandonnet E, Dezamis E, Psimaras D, Guyotat J, Peruzzi P, Page P, Gal B, Párraga E, Baron MH, Vlaicu M, Guillevin R, Devaux B, Duffau H, Taillandier L, Capelle L, Huberfeld G. Epileptic seizures in diffuse low-grade gliomas in adults. Brain 2014;137(Pt 2):449-62


Pallud J, Le Van Quyen M, Bielle F, Pellegrino Ch, Varlet P, Labussiere M, Cresto N, Dieme MJ, Baulac M, Duyckaerts C, Kourdougli N, Chazal G, Deveaux B, Rivera C, Miles R, Capelle L, Huberfeld G. Cortical GABAergic excitation contributes to epileptic activities around human glioma. Science Translational  Medicine. 2014; 6(244): 244ra89.

Blauwblomme T, Jiruska P, Huberfeld G. Mechanisms of ictogenesis. International Review of Neurobioogy 2014 ; 114: 155-85.

Huberfeld G, Becker AJ. Commentary: Morris-Coole/Epilepsia prize. Epilepsia 2014 ; 55(5): 640-1.

Dossi E, Blauwblomme T, Nabbout R, Huberfeld G, Rouach N. Multi-electrode array recordings of human epileptic postoperative cortical tissue. J Vis Exp. 2014 Oct 26;(92).

Alvarado-Rojas C, Huberfeld G, Baulac M, Clemenceau S, Charpier S, Miles R, Menendez de la Prida L, Le Van Quyen M. Different mechanisms contribute to ripple-like oscillations (100-250 Hz) in the human epileptic subiculum in vitro. Ann Neurol 2015;77(2):281-90

Huberfeld G, Blauwblomme T, Miles R. Hippocampus and epilepsy: findings from human tissues. Rev Neurol (Paris) 2015; S0035-3787(15)00589-5    

Huberfeld G, Pallud J. Brain tumors-related epilepsy. Pratique Neurologique – FMC 2015;6:19–33.

Huberfeld G, Kubis N. Electroencephalography in Intensive Care Unit. Réanimation 2015. DOI 10.1007/s13546-015-1098-7

Huberfeld G, Vecht Ch. Seizures and gliomas – towards a single therapeutic approach. Nature Review Neurology 2016 12(4) : 204-16.

Gataullina S, Lemaire E, Wendling F, Kaminska A, Watrin F, Riquet A, Ville D, Moutard ML, de Saint Martin A, Napuri S, Pedespan JM, Eisermann M, Bahi-Buisson N, Nabbout R, Chiron C, Dulac O, Huberfeld G. Epilepsy in young Tsc1(+/-) mice exhibits age-dependent expression that mimics that of human tuberous sclerosis complex.  Epilepsia. 2016.

Masson M, Huberfeld G. What do antiepileptic drugs cure? Positive effects and side effects of antiepileptic drugs in psychiatry. Annales Medico-Psychologiques 2016; 174 : 128–134. 

Masson M, Huberfeld G, Richa S, Henry C, Gaillard R. Caution and warning: About valproate and pregnancy. Encephale 2016 ;42(5):391-394.

Depauw A, Dossi E, Kumar N, Fiorini-Debuisschert C, Huberfeld G, Ha-Thi MH, Rouach N, Leray I. A Highly Selective Potassium Sensor for the Detection of Potassium in Living Tissues. Chemistry 2016 ;22(42):14902-14911.

Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin B. Reduced efficacy of the KCC2 cotransporter promotes epileptic oscillations in a subiculum network model. J Neurosci 2016, 36(46):11619-11633.

Horodyckid C, Canney M, Vignot A, Boisgard R, Drier A, Huberfeld G, François C, Prigent A, Santin MD, Adam C, Willer JC, Lafon C, Chapelon JY, Carpentier A. Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model. J Neurosurg. 2016; 10:1-11.

Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J. Epileptic seizures in anaplastic gangliogliomas. Br J Neurosurg. 2017 Apr;31(2):227-233    

Jozwiak S, Becker A, Cepeda C, Engel J Jr, Gnatkovsky V, Huberfeld G, Kaya M, Kobow K, Simonato M, Loeb JA. WONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients? Epilepsia. 2017 Apr 7. doi: 10.1111/epi.13728.

Vecht C, Duran-Peña A, Houillier C, Durand T, Capelle L, Huberfeld G. Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations. J Neurooncol. 2017 2017 Jul;133(3):603-607.  doi: 10.1007/s11060-017-2473-1.

Huberfeld G, Trebuchon A, Capelle L, Badier JM, Chen S, Lefaucheur JP, Gavaret M. Preoperative and intraoperative neurophysiological investigations for surgical resections in functional areas. Neurochirurgie 2017 pii: S0028-3770(17)30036-X

Vecht C, Royer-Perron L, Houillier C, Huberfeld G. Seizures and Anticonvulsants in Brain Tumours: Frequency, Mechanisms and Anti-Epileptic Management. Curr Pharm Des. 2017 Oct 27. doi: 10.2174/1381612823666171027130003. 

Dossi E, Blauwblomme T, Moulard, J, Chever O, Vassile F, Guinard E, Le Bert M, Couillin I, Pallud J, Capelle L, Huberfeld G, Rouach N, Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy. Sci. Transl. Med. 2018; 10, eaar3796.

Shorvon SD, Bermejo PE, Gibbs AA, Huberfeld G, Kälviäinen R. Antiepileptic drug treatment of generalized tonic-clonic seizures: An evaluation of regulatory data and five criteria for drug selection. Epilepsy Behav. 2018; 82:91-103.

Buchin A, Kerr CC, Huberfeld G, Miles R, Gutkin B. Adaptation and Inhibition Control Pathological Synchronization in a Model of Focal Epileptic Seizure. eNeuro. 2018 5;5(5)

Still MEH, Roux A, Huberfeld G, Bauchet L, Baron MH, Fontaine D, Blonski M, Mandonnet E, Guillevin R, Guyotat J, Taillandier L, Capelle L, Duffau H, Pallud J. Extent of Resection and Residual Tumor Thresholds for Postoperative Total Seizure Freedom in Epileptic Adult Patients Harboring a Supratentorial Diffuse Low-Grade Glioma. Neurosurgery. 2018 85(2):E332-E340

Blauwblomme T, Dossi E, Pellegrino C, Goubert E, Gal B, Varlet P, Rouach N, Nabbout R, Huberfeld G. Gamma-aminobutyric acidergic transmission underlies interictal epileptogenicity in pediatric focal cortical dysplasia. Ann Neurol. 2019;85(2):204-217.

Gataullina S, Bienvenu T, Nabbout R, Huberfeld G, Dulac O. Gene mutations in paediatric epilepsies cause NMDA-pathy, and phasic and tonic GABA-pathy. Dev Med Child Neurol. 2019 61(8):891-898

Menendez de la Prida L and Huberfeld G. Inhibition and oscillations in the human brain tissue in vitro. Neurobiology of Disease. 2019; 125:198-210.

Zanello M, Meyer B, Still M, Goodden JR, Colle H, Schichor C, Bello L, Wager M, Smits A, Rydenhag B, Tate M, Metellus P, Hamer PW, Spena G, Capelle L, Mandonnet E, Robles SG, Sarubbo S, Martino González J, Fontaine D, Reyns N, Krieg SM, Huberfeld G, Wostrack M, Colle D, Robert E, Noens B, Muller P, Yusupov N, Rossi M, Conti Nibali M, Papagno C, Visser V, Baaijen H, Galbarritu L, Chioffi F, Bucheli C, Roux A, Dezamis E, Duffau H, Pallud J. Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers. Seizure. 2019 Jul;69:31-40.

Cômes PC, Huberfeld G, Metellus P, Pallud J, Vercueil L, Peyre M. Management of tumoral epilepsy in meningioma surgery: review of the literature and survey of French national practices. Neurochirurgie. 2019 69:31-40. 

Milior G, Morin-Brureau M, Chali F, Le Duigou C, Savary E, Huberfeld G, Rouach N, Pallud J, Capelle L, Navarro V, Mathon B, Clemenceau S and Miles R. J Neurosci. 2020; 40(7):1373-1388.

Vrillon A, Carle G, Berzero G, Honnorat J, Huberfeld G, Psimaras D, Azuar C. Psychiatric symptoms in anti glutamic acid decarboxylase associated limbic encephalitis in adults: a systematic review. Neurosci Biobehav Rev. 2020;119:128-137. 

Alexandre Roux, Marc Zanello, rosella Mancusi, Megan Still, Fábio Augusto Nascimento, Arnault Tauziede-Espariat, Gilles Huberfeld, Gilles Zah-Bi, Edouard Dezamis, Jean-François Meder, Marie Bourgeois, Eduardo Parraga, Fabrice Chretien, Pascale Varlet, Catherine Oppenheim, Emmanuele Lechapt, and Johan G. Pallud. Meningioangiomatosis: Multimodal analysis and insights from a systematic review. Neurology 2020; 96(6):274-286

Cogo A, Mangin G, Maïer B, Callebert J, Mazighi M, Chabriat H, Launay JM, Huberfeld G,  Kubis N. The kynurenine pathway is a reliable biomarker of post-stroke cognitive decline. Molecular Neurodegeneration 2021;16(1):7.

Suarez-Castellanos, Dossi E, Vion-Bailly J, Salette L, Chapelon JY, Carpentier A, Huberfeld G, N'Djin WA. Spatio-temporal characterization of causal electrophysiological activity stimulated by single pulse focused ultrasound: an ex vivo study on hippocampal brain slices. Journal of Neural Engineering 2021; 18 (02): 6022.

Lambrecq V, Hanin A, Munoz-Musat E, Chougar L, Gassama S, Delorme C, CousynvL, Borden A, Damiano M, Frazzini V, Huberfeld G, Landgraf F, Nguyen-Michel VH, Pichit P, Sangare A, Chavez M, Morélot-Panzini C, Morawiec E, Raux M, Luyt CE, Rufat P, Galanaud D, Corvol JC, Lubetzki C, Rohaut B, Demeret S, Pyatigorskaya N, Naccache L, Navarro V; Cohort COVID-19 Neurosciences (CoCo Neurosciences) Study Group. Association of Clinical, Biological, and Brain Magnetic Resonance Imaging Findings With Electroencephalographic Findings for Patients With COVID-19. JAMA Netw Open 2021;4(3):e211489.

Huberfeld G, Ben Salah A, Pichit P, Psimaras D, Demeret S, Naccache L. Oculomotor artefacts mimic extreme deltabrush EEG features of autoimmune anti NMDA receptor encephalitis. Clin Neurophysiol 2021;132(6):1200-1202.

Dade M, Giry M, Berzero G, Benazra M, Huberfeld G, Leclercq D, Navarro V, Delattre JY, Psimaras D, Alentorn A. Quantitative brain imaging analysis of neurological syndromes associated with anti-GAD antibodies. Neuroimage Clin. 2021; 32: 102826.

Zanello M, Roux A, Gavaret M, Bartolomei F, Huberfeld G, Charlier P, Georges- Zimmermann P, Carron R, Pallud J. King Charles VIII of France's Death. From an unsubstantiated traumatic brain injury to more realistic hypotheses. World Neurosurg. 2021; S1878-8750(21)01399-1.

Huberfeld G, Le Van Quyen M. Cellular correlates of epileptic spikes with high-frequency oscillations in the human temporal lobe. Brain. 2021 Sep 28:awab349.

Pallud J, Huberfeld G, Dezamis E, Peeters S, Moiraghi A, Gavaret M, Guinard E, Dhermain F, Varlet P, Oppenheim C, Chrétien F, Roux A, Zanello M. Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wildtype Glioblastoma in Adults: An Observational Study. Neurology. 2021 Oct

Pallud J, Huberfeld G. Time to dispense with antiepileptic drug prophylaxis in brain tumor surgery? Neurochirurgie. 2021 Dec 31:S0028-3770(21)00263-0. 

Huberfeld G, Pallud J, Drouin E, Hautecoeur P. On St Teresa of Avila's mysticism: epilepsy and/or ecstasy? Brain. 2022 Aug 27;145(8):2621-2623

Pallud J, Huberfeld G. Author Response: Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wild-Type Glioblastoma in Adults: An Observational Study. Neurology. 2022 ;98(23):993.

Pallud J, Huberfeld G. Author Response: Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wild-Type Glioblastoma in Adults: An Observational Study. Neurology. 2022 ;99(2):85.

Gataullina S, Galvani G, Touchet S, Nous C, Lemaire É, Laschet J, Chiron C, Dulac O, Dossi E, Brion JD, Messaoudi S, Alami M, Huberfeld G. GluN2C selective inhibition is a target to develop new antiepileptic compounds. Epilepsia. 2022 ;63(11):2911-2924.

Bikfalvi A, da Costa CA, Avril T, Barnier JV, Bauchet L, Brisson L, Cartron PF, Castel H, Chevet E, Chneiweiss H, Clavreul A, Constantin B, Coronas V, Daubon T, Dontenwill M, Ducray F, Enz-Werle N, Figarella-Branger D, Fournier I, Frenel JS, Gabut M, Galli T, Gavard J, Huberfeld G, Hugnot JP, Idbaih A, Junier MP, Mathivet T, Menei P, Meyronet D, Mirjolet C, Morin F, Mosser J, Moyal EC, Rousseau V, Salzet M, Sanson M, Seano G, Tabouret E, Tchoghandjian A, Turchi L, Vallette FM, Vats S, Verreault M, Virolle T. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends Cancer. 2022 Nov 15:S2405-8033(22)00220-5.

Milior G, Morin-Brureau M, Pallud J, Miles R, Huberfeld G. Animal models and human tissue compared to better understand and treat the epilepsies. Epilepsia. 2023 May;64(5):1175-1189. doi: 10.1111/epi.17552. Epub 2023 Mar 6. PMID: 36807867

Dossi E, Huberfeld G. GABAergic circuits drive focal seizures. Neurobiol Dis. 2023 May;180:106102. doi: 10.1016/j.nbd.2023.106102. Epub 2023 Mar 26. PMID: 36977455.

Wenzel M, Huberfeld G, Grayden DB, de Curtis M, Trevelyan AJ. A debate on the neuronal origin of focal seizures. Epilepsia. 2023 May 15. doi: 10.1111/epi.17650. Epub ahead of print. PMID: 37183507.

Neuronal Signaling in Epilepsy & Glioma 

Institute of Psychiatry and Neuroscience of paris - IPNP

INSERM U1266 - Université Paris Cité

102-108 rue de la Santé - 75014 Paris



Adult epileptology and EEG Unit

Neurology department

Hopital Fondation Adolphe de Rothschild

29 rue Manin - 75019 Paris